Heparinase I
- Company Name:Adhoc Intertek Co., Ltd
- Membership:Free Member
- Member Since:2013. 05.28
- Country/Region:China
- City:Beijing
- Contact:Zak
- Related Keywords:heparinases, heparin
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Adhoc Intertek Co., Ltd
[China]
Heparinase I cleaves heparin and to a lesser extent heparan sulfate (ratio approx. 3:1).
Synonyms:Heparinase; heparin lyase; heparin eliminase
Gene Source: Native flavobacterium heparinum
EC Number: 4.2.2.7
CAS Number: 9025-39-2
MDL Number: MFCD00131317
MORE INFORMATION:http://www.aglyco.com/Products/Natural-Heparinases/AG00-2519
Catalyzed Reaction: The enzyme cleaves selectively, via an elimination mechanism, highly sulfated polysaccharide chains containing 1-4 linkages between hexosamines and O-sulfated iduronic acid residues. The reaction yields oligosaccharide products (mainly disaccharides) containing unsaturated uronic acids which can be detected by UV spectroscopy at 232 nm. The enzyme also cleaves the antithrombin III binding pentasaccharide domain in the heparin molecule.
Substrate Specificity: Heparin; heparan sulfate (specific activity with heparin is approx. 3 times higher than with heparan sulfate).
Properties:
Specific Activity: 100 IU/mg,1 IU/100 ul. One international unit (IU) is defined as the amount of enzyme that will liberate 1.0 m mole unsaturated oligosaccharides from porcine mucosal heparin per minute at 37 ℃ and pH 7.0.
Stability: expiration is 12 months from manufacturing date, frozen at -20 ℃ PBS.
Applications:
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